[11C]NOP-1A and Cocaine Use Disorders

Early Phase 1

Completed

• Conditions: Cocaine Use Disorder
• Interventions: Radiation: [C-11]; Drug: NOP-1A

• Registration Number: NCT03348384
• Lead Sponsor: University of Pittsburgh

Brief Summary

The goal of this study is to compared \[C-11\]NOP-1A binding in recently abstinent cocaine use disorders and controls.

Detailed Description

This will allow for understanding brain stress and anti-stress mechanisms that underlie abuse of cocaine in humans.

Study Timeline

• Study Start: 2014-10-30
• Study First Submitted: 2017-11-16
• Study First Submitted QC: 2017-11-16
• Study First Posted: 2017-11-20
• Primary Completion: 2019-02-20
• Study Completion: 2019-02-20
• Status Verified: 2019-08
• Last Update Submitted: 2019-08-02
• Last Update Posted: 2019-08-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 49

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cocaine use disorders	[C-11]	PET scan
Cocaine use disorders	NOP-1A	PET scan
Controls	[C-11]	PET scan
Controls	NOP-1A	PET scan

Primary Outcome Measures

Name	Time	Method
[C-11]NOP-1A VT	Baseline	VT-volume of distribution expressed relative to total plasma

Trial Locations

Locations (1)

University of Pittsburgh; 🇺🇸 Pittsburgh, Pennsylvania, United States