Early detection of breast cancer in women with a familial or genetic predisposition of developing breast cancer using biomarkers in serum
Recruiting
- Conditions
- Breast cancer, hereditary breast cancer
- Registration Number
- NL-OMON26238
- Lead Sponsor
- Genootschap Landgoed Keukenhof, A Sisters Hope, Pink Ribbon, Zabawas, Nuts-Ohra
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1250
Inclusion Criteria
Women
- 25-75 years old
- Screening indication due to familiar or genetically enhanced risk of developing breast cancer or LTR > 15%
Exclusion Criteria
- Previous invasive breast cancer in medical history
- Other malignancies within the last 10 years (other than basal cell carcinoma)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Analyzing the differences in protein profiles between patients and controls and within patients over time. Moreover, establishing a panel of protein-based biomarkers for the early detection of breast cancer.
- Secondary Outcome Measures
Name Time Method <br>The prognostic value of the selected protein profiles as biomarkers (5-year survival, disease free period and distant mestastasis)