Breast cancer screening examinations in women after Hodgkin's lymphoma therapy in childhood and adolescence (HD-78 to HD interval studies) with radiotherapy including areas of the mammary gland

Not Applicable

Recruiting

• Conditions: C50; C81; Malignant neoplasm of breast; Hodgkin lymphoma

• Registration Number: DRKS00004910
• Lead Sponsor: niklinik Köln

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 500

Inclusion Criteria

= 25 years, female, radiation of hodgkin´s disease including breast area in childhood and adolescence, no contraindication against one of the diagnostic procedures, informed consent

Exclusion Criteria

- = 50 years of age
- pregnancy, lactation
- contraindication for MRI of the breast (e.g. contrast agent allergy, pacemaker, defibrillator, epicardial wires, certain cochlear and ocular implants and heart valves, magnetically activated tissue expanders, tattoos containing metal in the examination area or osteosynthesis material due to the risk of overheating, patient at risk of nephrogenic systemic fibrosis)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prospective incidence of secondary breast cancers in women after radiation of Hodgkin´s disease including breast area in childhood and adolescence

Secondary Outcome Measures

Name	Time	Method
- Value (sensitivity, specificity, positive predictive value, negative predictive value) of the diagnostic procedures breast sonography, mammography, magnetic resonance imaging of the breast<br>- Early detection of secondary breast carcinomas <br>- Influence of early detection on breast carcinoma mortality