Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk

Not Applicable

Completed

• Conditions: Maternal Obesity Syndrome
• Interventions: Other: cross-sectional

• Registration Number: NCT01514539
• Lead Sponsor: University of Wyoming

Brief Summary

Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk Studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective.

Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity/

Detailed Description

Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk.

This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Eligibility Criteria: Healthy females, 18+ years old, non-smokers, no major food allergies, first-time mom, currently pregnant or within 1 month of giving birth.

Study Timeline

• Study Start: 2009-08
• Study First Submitted: 2012-01-09
• Study First Submitted QC: 2012-01-18
• Study First Posted: 2012-01-23
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Status Verified: 2015-01
• Last Update Submitted: 2015-01-07
• Last Update Posted: 2015-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 44

Inclusion Criteria

• Healthy women (non-smokers) at least 18 years old who did not have any pregnancy complications, and gave birth to their first child within one month.
• The study is open to women who are breastfeeding or formula feeding.

Exclusion Criteria

• Smoker,
• had twins or triples,
• had any major complication of pregnancy(example,
• gestational diabetes);
• have kidney, liver, hormonal, stomach, intestine,lung, heart or blood disease. This also includes high blood pressure;
• use prescription or over-the-counter medicine or herbal drinks or pills.
• History of depression, anxiety, disordered eating, other psychological problems, alcoholism or other substance abuse.
• Severely claustrophobic.
• Having a strong fear of needles and/or do not feel you can have blood drawn every 30 minutes from a plastic catheter.
• Are not able to or willing to fully participate in the study, and are pregnant, anemic or have a thyroid problem.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Never Pregnant	cross-sectional	women between 18 and 45 who have never been pregnant
Four weeks Postpartum Lactating	cross-sectional	women between 18 and 45 who delivered their first child 4 weeks prior and who were currently lactating and planning to lactate for one year postpartum.

Primary Outcome Measures

Name	Time	Method
"Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk"	5 years	Biomedical Research Study that will provide information on reducing maternal obesity.

Trial Locations

Locations (1)

Nutritional and Exercise Lab University of Wyoming; 🇺🇸 Laramie, Wyoming, United States