Combining Resting Blood Flow Restriction with Neuromuscular Electrical Stimulation: Effects on Blood Lactate Levels and Lower Limb Muscle Function

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: Blood Flow Restriction; Behavioral: Squat exercise; Device: Neuromuscular Electrical Stimulation

• Registration Number: NCT06196099
• Lead Sponsor: Hyunjoong Kim

Brief Summary

The current research landscape shows studies indicating increased muscle strength and hypertrophy through neuromuscular electrical stimulation combined with blood flow restriction. However, there is a lack of research specifically on the effects of this combination during rest periods. Therefore, the primary objective of this study is to investigate the impact of resting blood flow restriction training combined with neuromuscular electrical stimulation on blood lactate levels and changes in lower limb muscle function in healthy male adults.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-12-23
• Study First Submitted QC: 2023-12-23
• Study Start: 2023-12-30
• Study First Posted: 2024-01-09
• Primary Completion: 2024-01-11
• Study Completion: 2024-01-30
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-20
• Last Update Posted: 2025-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• Healthy adult males in their 20s,
• Individuals who answered less than one item on the PAR-Q (Physical Activity Readiness Questionnaire),
• Participants who consented to the use and publication of their physical function evaluation data and expressed a desire to participate in the exercise experiment.

Exclusion Criteria

• Individuals with severe hypertension (blood pressure above 170/110 mmHg),
• Individuals with a history of deep venous thrombosis,
• Individuals with endothelial dysfunction,
• Individuals with peripheral vascular disease,
• Individuals with one or more of the following conditions: diabetes, infection, cancer,
• Participants who expressed a desire to withdraw during the study period or whose participation rate was below 80% were excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
rest-Blood Flow Restriction plus Neuromuscular Electrical Stimulation	Blood Flow Restriction	-
rest-Blood Flow Restriction plus Neuromuscular Electrical Stimulation	Neuromuscular Electrical Stimulation	-
rest-Blood Flow Restriction	Blood Flow Restriction	-
Squat Exercise	Squat exercise	-

Primary Outcome Measures

Name	Time	Method
Blood lactate	Immediate change from baseline after intervention	Lactate levels were measured using the Accutrend Plus (Roche, Germany). A small amount of whole blood was collected from the participants for blood lactate concentration analysis. The procedure involved the finger-prick method, where the tip of the right index finger was disinfected with an alcohol swab. Then, a lancet prepared for this purpose was used to obtain a small sample of capillary blood from the disinfected area. The collected blood was then applied to lactate strips, and the blood lactate analyzer (Accutrend Plus, Roche, Germany) provided the lactate level readings within 60 seconds.

Trial Locations

Locations (1)

Honam University; 🇰🇷 Gwangju, Korea, Republic of