Resuscitation in Paediatric Sepsis Using Metabolic Support– A Randomized Controlled Trial to Assess Impact on Survival Free of Organ Dysfunction

niversity of Queensland0 个研究点目标入组 60 人开始时间: 2019年6月7日最近更新: 2021年6月14日

适应症

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•Children age =>28 days and <18 years which are admitted to the Paediatric Intensive Care Unit with a diagnosis of suspected septic shock requiring vasopressors/inotropes for >2hours (i.e. fluid-refractory shock).

•- Preterm babies born <34 weeks gestation that have a corrected age of <28 days
•- Known chronic renal failure not related to sepsis
•- Known chronic hepatic failure not related to sepsis
•- Known diseases affecting the steroid axis, including pituitary disease, congenital adrenal hypoplasia, Cushing or Addison’s disease
•- Palliative care patient/patient with limitation of treatment (not for inotropes, CPR, ECLS, intubation and ventilation)
•- Cardiopulmonary arrest in the past two hours requiring CPR >2 min, or death is deemed to be imminent or inevitable
•- Major bleeding with haemorrhagic shock
•- Sepsis is not likely to be the cause of shock
•- Known glucose-6 phosphate dehydrogenase (G-6PD) deficiency
•- Patients with sepsis/septic shock transferred form another ICU or hospital who have been treated with inotropes for septic shock for >24 hours
•- Patients with known history of oxalate nephropathy
•- Patients with acute beri-beri disease
•- Patients with acute Wernike’s encephalopathy
•- Patients with known malaria
•- Patients with known of suspected scurvy
•- Patient is receiving treatment for systemic fungal infection or has documented strongyloides infection at the time of randomization
•- Patient undergoing active chemotherapy for cancer treatment (incl. all administration routes)
•- Enrolment in RESPOND study <6 months ago (except for RESPOND ED randomization prior to RESPOND PICU within the same sepsis episode)

发起方

niversity of Queensland