Resuscitation in Paediatric Sepsis using Vitamin C and Hydrocortisone - A Randomized Controlled Multicentre Trial - assessing the effect on time alive and free of vasopressors

The University of Queensland0 个研究点目标入组 384 人开始时间: 2021年3月8日最近更新: 2022年2月21日

适应症

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•Criterion 1: Child aged >=7 days and <18 years and admitted to PICU.
•Criterion 2: Decision by treating physician to treat as sepsis (including parenteral antibiotics and inotropes)
•Criterion 3: Treatment of septic shock with vasopressor/inotrope therapy for >1 hour, or at a Vasopressor-Inotrope-Score of at least 10.
•Inotrope requirement will be calculated by means of the Vasoactive-Inotrope Score (VIS)63: VIS = dopamine dose (micgrogram/kg/min) + dobutamine dose (microgram/kg/min) + 100 x adrenaline dose (microgram/kg/min) + 100 x noradrenaline dose (microgram/kg/min) + 10 x milrinone dose (microgram/kg/min) + 10,000 x argipressin(vasopressin) dose (unit/kg/min). Note: vasopressin doses are often recorded as mU/kg/hour, which needs conversion to U/kg/min for the VIS score.

•- Preterm babies born <34 weeks gestation that have a corrected age of <7 days
•- Known chronic renal failure (defined as requiring continuous RRT prior to the onset of sepsis)
•- Palliative Care Patient/Patient with limitation of treatment (not for Inotropes, CPR, ECLS, Intubation and Ventilation)
•- Cardiopulmonary arrest in the past two hours requiring CPR >2 min, or death is deemed to be imminent or inevitable
•- Patients with sepsis/septic shock who have been treated with inotropes for septic shock for >24 hours
•- Patients with known glucose-6 phosphate dehydrogenase (G-6PD) deficiency
•- Patients with known history of oxalate nephropathy
•- Patients with known malaria
•- Enrolment in RESPOND study within the past 6 months

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