A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Peripheral Cytomegalovirus Retinitis in Patients With AIDS
- Conditions
- Cytomegalovirus RetinitisHIV Infections
- Registration Number
- NCT00000688
- Brief Summary
To provide information about the usefulness and safety of giving injections of ganciclovir (DHPG) for treating peripheral cytomegalovirus (CMV) retinitis.
CMV retinitis is an important sight-threatening opportunistic infection which affects 1 to 2 out of every 10 patients with AIDS. Results from an earlier study suggest that about 80 percent of patients with CMV retinitis will be helped by receiving intravenous doses of DHPG.
- Detailed Description
CMV retinitis is an important sight-threatening opportunistic infection which affects 1 to 2 out of every 10 patients with AIDS. Results from an earlier study suggest that about 80 percent of patients with CMV retinitis will be helped by receiving intravenous doses of DHPG.
Patients are randomly placed in one of two treatment groups. In one group, patients receive DHPG twice a day, intravenously, for 14 days, followed by a daily dose for 14 weeks. Patients in the other group (the delayed-treatment group) do not receive immediate treatment with DHPG. Patients in both groups have regular ophthalmologic (eye) evaluations with retinal photographs to see if the retinitis is getting worse. Patients in the delayed treatment group receive DHPG if this occurs.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 180
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (22)
Univ of California / San Diego Treatment Ctr
🇺🇸San Diego, California, United States
Stanford Univ School of Medicine
🇺🇸Stanford, California, United States
Kansas City Veterans Administration Med Ctr
🇺🇸Kansas City, Missouri, United States
Pacific Presbyterian
🇺🇸San Francisco, California, United States
George Washington Univ Med Ctr
🇺🇸Washington, District of Columbia, United States
Cornell Univ Med Ctr
🇺🇸New York, New York, United States
Indiana Univ Hosp
🇺🇸Indianapolis, Indiana, United States
New York Univ Med Ctr / Dept of Environmental Med
🇺🇸New York, New York, United States
Henry Ford Hosp
🇺🇸Detroit, Michigan, United States
Univ of Minnesota
🇺🇸Minneapolis, Minnesota, United States
Mills Hosp
🇺🇸San Mateo, California, United States
Infectious Disease Physicians Inc
🇺🇸Annandale, Virginia, United States
Washington Univ Med Ctr
🇺🇸St Louis, Missouri, United States
Mount Zion Med Ctr
🇺🇸San Francisco, California, United States
Infectious Diseases Association of Houston / Methodist Hosp
🇺🇸Houston, Texas, United States
Holmes Hosp / Univ of Cincinnati Med Ctr
🇺🇸Cincinnati, Ohio, United States
Univ of New Mexico Hlth Sciences Ctr / Dept of Med
🇺🇸Albuquerque, New Mexico, United States
Univ TX Galveston Med Branch
🇺🇸Galveston, Texas, United States
Plaza Med Ctr
🇺🇸Houston, Texas, United States
Stanford at Kaiser / Kaiser Permanente Med Ctr
🇺🇸San Francisco, California, United States
Northwestern Univ Med School
🇺🇸Chicago, Illinois, United States
Rush Presbyterian - Saint Luke's Med Ctr
🇺🇸Chicago, Illinois, United States