Metabolic Study of Concentric and Eccentric Muscle Training

Not Applicable

Completed

• Conditions: Lipid Metabolism; Insulin Resistance; Inflammation

• Registration Number: NCT00386854
• Lead Sponsor: Vorarlberg Institute for Vascular Investigation and Treatment

Brief Summary

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Detailed Description

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

Study Timeline

• Study Start: 2003-04
• Study Completion: 2003-08
• Status Verified: 2006-10
• Study First Submitted: 2006-10-10
• Study First Submitted QC: 2006-10-10
• Last Update Submitted: 2006-10-10
• Study First Posted: 2006-10-12
• Last Update Posted: 2006-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• healthy men and women
• age over 30 years

Exclusion Criteria

• previous systematic endurance training (≥3 times per week ≥30 min)
• body mass index >30 kg/m2
• heavy smoking (>20 cigarettes per day)
• regular alcohol consumption >60g per day
• established musculoskeletal disease
• history of cardiovascular disease
• diabetes mellitus
• unwillingness to stay in the area for the whole study period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.

Secondary Outcome Measures

Name	Time	Method
Metabolic and anti-inflammatory effects induced by concentric muscle exercise.

Trial Locations

Locations (1)

Vorarlberg Institute of Vascular Investigation and Treatment; 🇦🇹 Feldkirch, Vorarlberg, Austria