NCT00253006终止不适用
A Quantitative Analysis of Protein- and mRNA-Expression of Nitric Oxide Syntheses and Their Functional Role in Human Urothelium
Copenhagen University Hospital at Herlev1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2006年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 60
- 试验地点
- 1
研究概览
简要总结
Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes in many tissues.
The goal of this study is to illuminate bladder tissue production of NO in individuals with PBS and healthy individuals, by quantification of NO and NO-enzyme expression by different molecular biological methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PBS/IC according to International Continence Society (ICS)
- •Cystoscopy with bladder distension and deep biopsies within last 5 years
- •Cystometry within last 5 years
- •Normal urine culture within last month
- •Inclusion Criteria (for control group):
- •Benign non-invasive bladder disease
- •No PBS/IC
- •Normal urine culture
- •No functional bladder disease of known nature (ex. infravesical obstruction)
排除标准
- •Age under 18 years
- •Inability to understand instructions
- •Pregnancy and lactation
研究者
研究点 (1)
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