A prospective comparative study between conventional fractionated radiotherapy and hypofractionated radiotherapy by using 3D-CRT technique with respect to toxicity and quality of life in postmastectomy breast carcinoma.

Chittaranjan National Cancer Institute0 个研究点目标入组 52 人开始时间: 待定最近更新: 2024年5月27日

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•1.Age greater than equal to 18years and less than 70years.
•2.Female breast cancer patients.
•3.Histopathologically proven Infiltrating Ductal and Infiltrating Lobular carcinoma of the
•4.Patients who will undergo Modified Radical Mastectomy with adequate Axillary
•Dissection in our institution and will be indicated for post mastectomy chest wall
•radiotherapy.
•5.Breast carcinoma patients with documented ER,PR and Her2neu status.
•6.No other primary malignancy in any other parts of the body.
•7.No history of previous any chest wall irradiation.
•8.Eastern Cooperative Oncology Group(ECOG) Performance status 0-2.
•9.Patients without any serious co-morbidities like IHD,CVA,Coagulation and Bleeding
•10.Patients with normal haematological findings of Hb greater than 10gm/dl,TLC greater than 4000/cumm and
•Platelet Count of greater than 1lacs/cumm.
•12.Patients with normal Kidney and Liver Function Test.
•13.Patients with normal Pulmonary Function Test.
•14.Patients who will give consent to participate in the study.

•1.Age <18 years and >70years.
•2.Male breast cancer patients.
•3.Patients with a histopathological finding other than Invasive Lobular and Ductal
•4.Breast carcinoma patients withdistant metastasis.
•5.Patients with inoperable,clinically fixed,and matted lymph nodes.
•6.Patients with inadequate or no axillary dissection.
•7.Patients with any other primary malignant tumour.
•8.Patients with any chronic dermatological or connective tissue disorders that may interfere
•with radiation induced acute skin toxicity assessment.
•9.History of any previous chest wall irradiation.
•10.Patients with Eastern Cooperative Oncology Group(ECOG)Performance Score >2.
•11.Patients with serious active comorbidities like:
•History of unstable angina and/or congestive heart failure requiring hospitalization in the
•last 6months.
•*History of myocardial infarction within the last 6months.
•Acute or chronic bacterial or fungal infection requiring intravenous antibiotics at the
•time of patient registration.
•Chronic Obstructive Pulmonary Disease with abnormal Pulmonary Function Test.
•Clinical jaundice and bleeding disorders
•12.Patients with deranged Liver and Kidney function test results
•13.Patients who are HBsAg,Anti HCV antibody and HIV reactive.**

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