TDCS for Laryngeal Dystonia

Not Applicable

Not yet recruiting

• Conditions: Laryngeal Dystonia

• Registration Number: NCT06830174
• Lead Sponsor: Yale University

Brief Summary

This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).

Detailed Description

Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-11
• Study First Submitted QC: 2025-02-11
• Last Update Submitted: 2025-02-11
• Study First Posted: 2025-02-17
• Last Update Posted: 2025-02-17
• Study Start: 2025-03
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
• No other known or history of speech, voice disorder other than LD.
• Provision of signed and dated informed consent form.
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Must not be pregnant.

Exclusion Criteria

• All individuals who do not meet the above mentioned criteria are excluded from the study.
• Subjects with a history of epilepsy or depression or is claustrophobic.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in Cepstral peak prominence (CPP)	daily on Day 1-Day 5	Cepstral peak prominence (CPP) as a robust objective measure of voice quality in the active, sham and no stimulation conditions.
Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V)	daily on Day 1-Day 5	Its primary purpose is to describe the severity of auditory-perceptual attributes of a voice problem, in a way that can be communicated among clinicians

Trial Locations

Locations (1)

Child Study Center at 300 George Street; 🇺🇸 New Haven, Connecticut, United States