Comparative Resistance Exercise Effect on Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Knee Osteoarthritis
- 发起方
- University of Florida
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months
- 状态
- 已完成
- 最后更新
- 11年前
概览
简要总结
The purpose of this study is to determine if a 4 month resistance exercise program can reduce knee osteoarthritis pain functional impairment and cartilage turnover.
研究者
入排标准
入选标准
- •Osteoarthritis (OA) of the knee for \>6 months
- •moderate to severe pain immediately following a 50-foot walk
- •knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
- •bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
- •willing and able to participate in regular exercise for four months
- •free from musculoskeletal limitations that would preclude resistance exercise participation
- •free of abnormal cardiovascular responses during the screening graded maximal walk test
排除标准
- •unable to walk
- •regular resistance exercise training (\>3X week) within the past 6 months
- •specific low back pain or acute back injury
- •spinal stenosis that precludes walking one block due to neurogenic claudication
- •any major injury to either knee within the prior 12 months
- •any surgery to either knee within the last 12 months
- •lumbar radiculopathy
- •vascular claudication
- •significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
- •have had corticosteroid or viscosupplement injections within three months of study participation
结局指标
主要结局
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months
时间窗: Baseline, 4 Months
The WOMAC is a standard, multidimensional, self-administered functional-health status instrument for patients with lower limb OA. Subjects will complete the self-assessment at the time intervals indicated to document any change in their perception of their functional health status. Scale for Total score: the higher score means the worst the function and pain Total WOMAC scores will have a range of 0 to 96 (best and worst scores possible). 0-20 Womac pain (0= best, 20=worst) 0-8 Womac stiffness (0= best, 8=worst) 0-68 Womac functional (0= best, 68=worst) 0-96 Womac Total (0= best, 96=worst)
次要结局
- Chest Press; Change From Baseline at 4 Months(Baseline, 4 Months)
- Six Minute Walk Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Chair Rise Time and Stair Climb Time; Change From Baseline at 4 Months(Baseline, 4 Months)
- Leg Press Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Leg Extensions Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Leg Curl Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Shoulder Press Test; Change From Baseline at 4 Months(Baseline, 4 Months)
- Seated Row Test; Change From Baseline at 4 Months(Baseline, 4 Months)