Multicenter and Prospective Clinical Registry Study of Autoimmune Encephalitis in China
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 400
- 主要终点
- death
研究概览
简要总结
In recent years, more and more previously thought to be unknown encephalitis was found to be a specific antigen associated encephalitis，but because of the lack of recognition in the clinic, usually been misdiagnosed as other causes of encephalitis. Therefore, it is urgent to establish a database of autoimmune encephalitis in Chinese population. The prospective clinical trial of atutoimmune encephalitis in China, by screening the autoimmune encephalitis associated antibody and summarizing the cases analysis, in order to provide evidence for clinical diagnosis and treatment of autoimmune encephalitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Older than 6 months.
- •Encephalopathy symptoms (change of mental state and consciousness level) persist for more than 24 hours;
- •At least one or more clinical features of the followings: fever, epilepsy, focal neurological deficiency symptoms, changes in CSF(cerebrospinal fluid inflammatory), changes in EEG (electroencephalogram), radiographic abnormalities;
- •Clinical suspected encephalitis, but conventional detected methods cannot make etiology clear.
- •Signed the informed consent.
排除标准
- •Infants less than 6 months;
- •The metabolic encephalopathy;
- •Infectious encephalitis with clear pathogen clinically, referring the specific pathogenic microorganisms, including: bacteria, virus, fungus, parasite, spirochete and so on;
- •Non-infectious encephalitis with clear diagnosis clinically, including: multiple sclerosis, neuromyelitis optic, acute disseminated encephalomyelitis and so on.
结局指标
主要结局
death
时间窗: 30days
次要结局
未报告次要终点
研究者
Jia Wei Wang,MD
Chairman and Full Professor of Department of Neurology and Medical Research Center
Beijing Tongren Hospital