Study of 12 Cases of Autoimmune Encephalitis With Anti-NMDA Receptor Antibodies Following Herpetic Encephalitis and Review of the Literature
试验速览
- 阶段
- 不适用
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Details of clinical, biological, imaging, therapeutic characteristics and patient's evolution.
研究概览
简要总结
Herpes Simplex Virus encephalitis is the most common infectious encephalitis, with an estimated annual incidence of 1 / 250,000 to 1 / 500,000 in industrialized countries. Despite a widely used antiviral treatment, the prognosis remains poor with a mortality of 5 to 20% and a considerable morbidity rate.
One of the contributing factors of bad prognosis is the development of encephalitis mediated by autoantibodies, most often directed against NMDA receptors, in the weeks following viral encephalitis.
The description of this pathology is recent, the pathophysiology of this process remains poorly understood, and the management of these patients is not yet codified.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical autoimmune encephalitis with anti-NMDA antibodies and documented by CBA in the CSF
- •After a herpetic encephalitis documented by a positive viral PCR for HSV in the CSF
- •Without age limit
- •Exclusion Criteria- No respect of inclusion criteria
排除标准
- 未提供
结局指标
主要结局
Details of clinical, biological, imaging, therapeutic characteristics and patient's evolution.
时间窗: at 6 and 12 months
Retrospective collection of clinical, diagnostic and therapeutic data, evolution at 6 and 12 months.
次要结局
未报告次要终点