Study of Acute Autoimmune Encephalitis With Positive Antibodies in Eastern France
- Conditions
- Acute Autoimmune Encephalitis
- Registration Number
- NCT05605223
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
The number of acute encephalitides diagnosed each year is gradually increasing, reaching approximately 5 to 10/100,000 per year; more than 50% of etiologies currently remain unknown. The majority of them are acute encephalitis of infectious origin, but it is estimated that 20% of encephalitis in northern Europe is related to an autoimmune mechanism with the majority of encephalitis with anti-NMDA Ac discovered recently in 2007. The study of a large American encephalitis cohort showed a death rate of 3% to 7% in cases of autoimmune encephalitis. Furthermore, delay in the initiation of effective treatment (tumor removal or immunotherapy) beyond 4 weeks is associated with a poor prognosis at 1 year.
It is therefore necessary to better understand the signs of autoimmune encephalitis in order to recognize the disease quickly and to start a treatment quickly; in order to improve the management and the prognosis of these children.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Retrospective description of autoimmune encephalitis in children Files analysed retrospectively from January 01, 2006 to December 31, 2018 will be examined
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Service de Pédiatrie 1 - CHU de Strasbourg - France
🇫🇷Strasbourg, France
Service de Pédiatrie 1 - CHU de Strasbourg - France🇫🇷Strasbourg, France