Cerebral blood flow and cognition in diabetes: A pilot cross-sectional investigatio

Not Applicable

Completed

• Conditions: Cerebral blood flow pulsatility; Cognitive performance; Cerebral blood flow; Metabolic and Endocrine - Diabetes; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12613000457741
• Lead Sponsor: Prof Peter Howe

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-04-19
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Age 50 – 80 years, females must be post-menopausal (self-reported cessation of menses for at least 12 months)
2. Have non-insulin-dependent diabetes as diagnosed by a doctor and fasting plasma glucose greater than or equal to 7.0mM or have fasting plasma glucose less than or equal 5.5mM, determined by the results obtained in the Hunter Pathology test.

Exclusion Criteria

1. Unwilling to fast for at least 8 hours
2. A smoker or currently on nicotine therapy
3. Have dementia or suspected dementia (MMSE score less than 25 at screening visit)
4. Have a history of serious head injury, alcoholism, stroke and/or neurological condition
5. Have no measurable TCD ultrasound signal (determined during the screening visit)
6. Unable to read and write English fluently
7. Have changed their diabetes medication in the last three months

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebral blood flow pulsatility in type 2 diabetes versus age-matched controls, assessed by TCD ultrasound (peak systolic flow - end-diastolic flow/mean blood velocity in the middle cerebral artery).[Four continuously recording of blood flow velocity through 10 cardiac cycles, after 10 mins of seated rest in silence at baseline and 1 week later in a subset of volunteers.]