AntiInflammatory effect of Sertraline in haemodialysis patients
Phase 2
- Conditions
- depression.Depressive episode
- Registration Number
- IRCT201111228171N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1- Age between 18 to 80 years; 2- start to Haemodialysis of at least 3 months duration; 3- Receiving maintenance haemodialysis, 4 hour three times per week via a low flux polysulphone dialyser using bicarbonate dialysis fluid; 4- presence of depression based on Beck Depression Inventory (BDI). Exclusion criteria : 1- Patients with major acute infections, autoimmune disease, cancer, severe mental illness, cognitive dysfunction; 2- taking immunosuppressive agents like corticoestroieds for at least 1 month; 3- taking antiinflammatory drugs such as NSAIDs 3-Current use of an antidepressant medication; 4-Intolerance of Sertraline adverse effects.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression. Timepoint: Baseline, 6 and 12 weeks after. Method of measurement: Beck Depression Inventory (BDI).
- Secondary Outcome Measures
Name Time Method Inflammation stutus. Timepoint: Baseline, 6 and 12 weeks after. Method of measurement: Inflammatory Cytokines (TNF-a, IL-6, IL-10, hs-CRP).