Evaluation of Duloxetine effect on Oxaliplatin induced peripheral neuropathy prophylaxis
Phase 3
Recruiting
- Conditions
- colorectal cancer.malignant neoplasm of colon
- Registration Number
- IRCT20100127003210N15
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Over 18 years old
The candidate patient is going to get his/her first chemotherapy course with Oxaliplatin drug
Exclusion Criteria
The patient has no uncontrolled diabetes mellitus or uncontrolled hypertension
The patient is not taking drugs which have interaction with Duloxetin
The patient is not on liver metastatic stage
History of duloxetine allergy
hepatic impairment
clcr < 30ml/min and ESRD
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peripheral neuropathy. Timepoint: every 2-3 week. Method of measurement: FACT/GOG-NTX-13 and NCI-CTCAE questionaire.
- Secondary Outcome Measures
Name Time Method Quality of life. Timepoint: at baseline and 12 weeks later. Method of measurement: FACT-C version 4 questionaire.