Effect of 25-hydroxy vitamin D on inflammation and bone-turnover in critically ill patients
Completed
- Conditions
- Inflammation/calcium and bone metabolismNutritional, Metabolic, EndocrineVitamin D deficiency
- Registration Number
- ISRCTN24385496
- Lead Sponsor
- Catholic University Leuven (Katholieke Universiteit Leuven) (Belgium)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
1. Patients admitted to any of the four intensive care units with an anticipated Intensive Care Unit (ICU) stay of greater than 10 days
2. Older than 18 years, either sex
Exclusion Criteria
1. Younger than 18 years
2. Patients suffering from chronic bone disease
3. Patients suffering from parathyroid disease
4. Patients suffering from chronic kidney disease
5. Patients known to be pregnant or nursing
6. Prior treated with glucocorticoids before ICU admission
7. Patients with a 'do not resuscitate' (DNR) code at the time of ICU admission
8. Patients already enrolled in another trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Inflammation and innate immunity patterns, daily during study period (from day 0 till day 10)<br>2. Bone turnover and vitamin D status: via blood and urine analyses, daily during study period (from day 0 till day 10)
- Secondary Outcome Measures
Name Time Method 1. Infections, during ICU stay: from admission untill ICU discharge<br>2. Organ function: Apache (measured upon ICU admission) and Sequential Organ Failure Assessment (SOFA) (measured daily during study period [from day 0 till day 10]) scores<br>3. ICU stay, measured upon discharge<br>4. Mortality (ICU, hospital), measured during ICU stay and hospital stay