Pilot Study of Cancer Resistance in Humans
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cancer
- Sponsor
- Wake Forest University Health Sciences
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Cell killing ability (positive or negative)
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
PURPOSE: This laboratory study is looking at an assay in determining cancer resistance in patients with metastatic cancer and in healthy participants.
Detailed Description
OBJECTIVES: * Optimize and standardize the in vitro cell kill assay using human white blood cells and human cancer cell lines from patients with metastatic cancer and from healthy participants. * Determine the results of the in vitro cell kill assay in patients with metastatic cancer and in healthy participants with no history of cancer. OUTLINE: This is a pilot study. Peripheral blood is obtained from healthy participants and from cancer patients. Tissue is collected from archived samples. White blood cells are obtained from tissue and blood samples and are assessed by the in vitro cell kill assay. PROJECTED ACCRUAL: A total of 24 patients and 24 healthy participants will be accrued for this study.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Meets 1 of the following criteria:
- •Diagnosis of metastatic cancer including, but not limited to, any of the following:
- •Stage IV non-small cell lung cancer
- •Extensive-stage small cell lung cancer
- •Metastatic testicular cancer
- •Stage IV breast carcinoma
- •Stage III or IV ovarian carcinoma
- •Stage IV endometrial carcinoma
- •Stage IV prostate carcinoma
- •Stage IV colorectal or pancreatic cancer
Exclusion Criteria
- •Serious medical or psychiatric condition that would preclude study compliance
- •Chemotherapy or radiotherapy within the past 3 months (patient)
- •Prior immunosuppressive therapy or radiotherapy for any disease (healthy participant)
Outcomes
Primary Outcomes
Cell killing ability (positive or negative)
Time Frame: Day 180
Percentage of cells killed
Time Frame: Day 180