PLUTO: A randomised clinical trial comparing PlasmaLyte fluid to standard care for children receiving a kidney transplant

Phase 4

Completed

• Conditions: Prevention of hyponatremia in children undergoing kidney transplant; Injury, Occupational Diseases, Poisoning; Kidney transplantation in paediatric patients with end-stage kidney disease

• Registration Number: ISRCTN16586164
• Lead Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust

Brief Summary

2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35288387/ protocol (added 25/03/2022) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37914088/ (added 05/12/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-10
• Study Completion: 2022-11-17
• Last Update Posted: 8 January 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 144

Inclusion Criteria

1. Children expected to be under 18 years of age at the time of transplantation
2. Children undergoing preparation for living or deceased donor kidney only transplantation, or active on the deceased donor transplant waiting list for a kidney only transplant at participating UK paediatric transplant centres either pre-emptively (not currently receiving dialysis) or patients on dialysis

Exclusion Criteria

1. Multi-organ transplant recipients

Study & Design

• Study Type: Interventional
• Study Design: Not specified