Evaluating the effects of yogurt containing probiotics in treating gastroesophageal reflux disease
- Conditions
- Gastroesophageal reflux disease (GERD).Gastro-esophageal reflux disease
- Registration Number
- IRCT20190831044653N4
- Lead Sponsor
- Bojnourd University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 120
The patient be literate or someone helps him/her in filling the questionnaires
Patients should be geographically accessible
Age less than 18 years
Allergy to dairy products
Pregnancy
History of gastrointestinal malignancy
History of gastric and esophageal surgery and small bowel bypass
Liver and kidney and heart dysfunction
Concomitant use of NSAIDs and aspirin for up to one week before the study
Anticancer or antibiotic use during 4 weeks before referral and participation in this study
No anti-acid, hydrogen pump inhibitors, H2 receptor inhibitors in two groups of yogurt recipients during the study
Receiving bisphosphenate, cortisone, potassium chloride or iron tablets concurrently in the study
Patient's compliance be less than 80% (self-reported by patient)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect on the GERD severity. Timepoint: Baseline, one month and tow months later. Method of measurement: The Gastroesophageal Reflux Disease-Health Related Quality of Life instrument (related to typical symptoms).;Effect on the severity of GERD atypical symptoms. Timepoint: Baseline, one month and tow months late. Method of measurement: Reflux Symptom Index and Disease Specific Quality of Life Index questionnaires (related to atypical symptoms).
- Secondary Outcome Measures
Name Time Method Assessment of quality of life. Timepoint: At baseline, one month and tow months later. Method of measurement: questionnaire.