Clinical Parameters and Biological Markers associated with Acute Severe Ocular Complications in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Thailand

Completed

• Conditions: Acute Ocular Complications in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Thailand; Stevens-Johnson Syndrome; Toxic Epidermal Necrolysis; Severe cutaneous adverse reaction; SCAR; Type IV hypersensitivity reaction; Delayed T-cell-mediated type hypersensitivity reaction; Drug-induced SJS and TEN; Drug reaction; Culprit drugs

• Registration Number: TCTR20210729002
• Lead Sponsor: Ratchadapisek Sompoch Endowment Fund

Brief Summary

The disease (TEN or SJS) and older age were predicting factors for acute SOCs in SJS/TEN. - The S100A8/A9 and granulysin levels tended to increase in the severe ocular involvement group, suggesting that S100A8/A9 and granulysin might involve in the pathogenesis of severe ocular involvement and serve as a helpful biomarker to evaluate SOCs in acute SJS/TEN.

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-01-31
• Study Start: 2021-07-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

1. Patients in Thai SCARs database (dermatological diagnosis of SJS or TEN or SJS-TEN overlap) with ocular involvement
2. The patients had medical records of the acute phase, which were fully accessible to evaluate prognostic factors
3. The patients did not have a history of other ocular surface disorder or ocular surgery

Exclusion Criteria

1. Clinical information was insufficient to calculate the SCORTEN
2. Sepsis (in serum analysis)
3. Positive blood culture (in serum analysis)

Study & Design

• Study Type: Observational
• Study Design: Not specified