Creatine Supplementation and Cognitive and Physical Tests

Not Applicable

Completed

• Conditions: Healthy; Creatine Supplementation
• Interventions: Dietary Supplement: Calcium lactate; Dietary Supplement: Creatine

• Registration Number: NCT03352128
• Lead Sponsor: Vrije Universiteit Brussel

Brief Summary

To assess whether brain creatine availability has an effect on cognition. To do so we will seek to increase brain creatine concentration via a creatine supplementation protocol.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-11-08
• Study First Submitted QC: 2017-11-21
• Study First Posted: 2017-11-24
• Study Start: 2018-09-10
• Primary Completion: 2019-03-28
• Study Completion: 2019-03-28
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-04
• Last Update Posted: 2019-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Healthy (No neurological illness including cardiovascular, renal, and endocrine disorder)
• Male/female
• No medication / supplements
• Non-smoker
• Low to moderately active
• Between 18 and 35 years old

Exclusion Criteria

• Injuries
• Illness
• Use of medication
• Use of creatine in the last 3 months
• History of head trauma or seizure
• Vegetarian diet [24]
• Not being able to follow up the restrictions and prohibitions for the subjects (see Restrictions and prohibitions for the subjects)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo supplementation	Calcium lactate	7-day calcium lactate supplementation
Creatine supplementation	Creatine	7-day creatine supplementation

Primary Outcome Measures

Name	Time	Method
Cognitive performance - change in accuracy (%) during a 90-min cognitive task (i.e. Stroop task)	During both lab visits (i.e. after both 7-day supplementation protocols); Accuracy (%) will be assessed during both lab visits with a 90-min cognitive task; Accuracy during the 90-min task will be reported as mean accuracy during 8 blocks of 11min15sec	Accuracy (in %) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)
Cognitive performance - change in reaction time (milliseconds) during a 90-min cognitive task (i.e. Stroop task)	During both lab visits (i.e. after both 7-day supplementation protocols); Reaction time (RT) will be assessed during both lab visits with a 90-min cognitive task; RT during the 90-min task will be reported as mean RT during 8 blocks of 11min15sec	Reaction time (in milliseconds) will be assessed during a cognitive task, this cognitive task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Secondary Outcome Measures

Name	Time	Method
Physical performance - reaction time (milliseconds) during a 7-min visuomotor reaction time task	During both lab visits (i.e. after both 7-day supplementation protocols); visuomotor reaction time will be assessed during both lab visits with a 7-min visuomotor reaction time task.	Reaction time (in milliseconds) will be assessed during a visuomotor reaction time task, this physical task will be completed after both 7-day supplementation protocols (i.e. placebo and creatine)

Trial Locations

Locations (1)

Human Physiology and Sports Physiotherapy Research Group; 🇧🇪 Brussels, Belgium