Effects of Ten-Weeks Power Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Testing sessions; Other: Resistance training

• Registration Number: NCT04276324
• Lead Sponsor: Universidad Católica San Antonio de Murcia

Brief Summary

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-02-17
• Study First Submitted QC: 2020-02-18
• Study First Posted: 2020-02-19
• Study Start: 2020-03-10
• Primary Completion: 2020-06-15
• Status Verified: 2020-10
• Study Completion: 2020-10-15
• Last Update Submitted: 2020-10-22
• Last Update Posted: 2020-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• mild or moderate disability with clinical mild spastic-ataxic gait disorder.
• stable phase of the disease.

Exclusion Criteria

• Expanded Disability Status Scale (EDSS) < 6.
• relapsing disease within the preceding 12 months.
• corticosteroid treatment within the last months before study inclusion.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Group	Testing sessions	Only testing sessions
Resistance training group	Resistance training	Ten weeks of resistance training
Resistance training group	Testing sessions	Ten weeks of resistance training

Primary Outcome Measures

Name	Time	Method
Spasticity	After 10 weeks	Pendulum test
Maximal Voluntary Isometric Contraction of Knee Extension	After 10 weeks
Rate of Force Development	After 10 weeks
Central Activation Ratio	After 10 weeks

Secondary Outcome Measures

Name	Time	Method
Functional capacity	After 10 weeks	Sit to stand test
Walking speed	After 10 weeks	Test 10 m-walks
Static balance	After 10 weeks	Romberg Test with eyes open and closed. Analysis with force plates
Heart Rate Variability	After 10 weeks	Sleeping Heart Rate Variability
Sleep Quality	After 10 weeks	Karolinska Sleep Diary and Acelerometry

Trial Locations

Locations (1)

Universidad Católica San Antonio; 🇪🇸 Murcia, Spain