Postoperative time of extubation and incidence of postoperative nausea and vomiting due to intraoperative pupillometry-controlled analgesia

Not Applicable

• Conditions: postoperative nausea and vomitinganalgesia

• Registration Number: DRKS00012329
• Lead Sponsor: Klinik für Anästhesiologie, Intensiv-, Palliativ- und Schmerzmedizin; Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bochum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-24
• Study Completion: 2019-10-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

voluntariness; preoperative written confirmed consent, elective surgery with use of heart-lung machine or implantation of transapical aortic valve (TAVI), adequate knowledge of the German language, 18 years of age

Exclusion Criteria

< 18 years; withdrawal of agreement; employees of the investigator or of the facility that is participating in this clinical research oder other studies; simultaneous participation in an AMG-study; emergency surgery; glass eye; anisocoria, non-treated hypertension, advanced Dibates mellitus HbA1C >8.5%, concomitant treatment with opioids or antidepressants, eye drugs for topical application, psychiatric disorder.
Secondary: BDI > 20 points, early postoperative complications, intraopertive injection of atropine, MCP/ DHB, intraopertive hypothermia <32°C.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• Patients who undergo elective cardiac surgery and receive intraoperative opioids due to pupillometry will be extubated earlier than patients who receive opioids due to clinical parameters (without pupillometry)<br>• Patients with cardiac surgery and intraoperative analgesia due to pupillometry will suffer less postoperative nausea and vomiting than patients who receive opioids due to clinical parameters (without pupillometry)

Secondary Outcome Measures

Name	Time	Method
• Postoperative pain (NRS, numerical rating scale, 0-10) on day one and day two after surgery<br>• Incidence of re-Intubation with early respiratory insuffiency (< 24h after extubation).<br>• Intraoperative consumption of analgesics<br>• Postoperative consumption of analgesics on day one and day two after surgery.<br>• Incidence of postoperative delirium on day one and two after surgery.<br>• Intraoperative correlation between pupillometry and BIS.<br>• gender difference for all diagnosed parameter (z.B. PONV, NRS pupil diameter).<br>• Incidence rate on further postoperative complications on day one and two after surgery.