Comparison of two treatment options for hypertension in heart transplant recipients

IKEM0 个研究点目标入组 40 人开始时间: 2011年4月13日最近更新: 2024年9月2日

适应症

试验速览

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•Patients aged between 18-65 years ,who are undergoing heart transplantation, and who develop hypertension during the first 6 months, which will require treatment
•2) A patient who understands the purpose of the study, which was fully informed and gave written consent to participate in the study
•3) blood pressure> 130/80 mmHg
•4) The value of serum potassium <5 mmol / l
•5) Serum creatinine lower or equal than 150 micromol / l glomerular filtration rate > 1.0 ml / s
•6) No serious complications associated with surgery (graft failure ,hemodynamic instability, severe acute rejection, renal failure)
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•1) Patient after heart transplantation more than 6 months
•2) The presence of serious complications after heart transplantation (graft failure,
•hemodynamic instability, severe acute rejection)
•3) Hyperkalemia (serum potassium concentration> 5.3 mmol / l)
•4) Current use of potassium-sparing diuretics
•5) Patients with significant renal impairment defined as an increase creatinine higher or equal to 250 umol/l
•6) Patients with significantly elevated liver function tests (defined as AST and ALT
•increased to three times the normal values
•7) Anemia (hemoglobin <90 g / l)
•8) Retransplantation or multiorgan transplantation
•9) Women who are unable or unwilling to use two barrier contraception
•10) Pregnant women or nursing mothers
•11) Inability to take oral medication
•12) Patients unable to give informed consent
•13) Patients with mental disorder or condition, which in the opinion investigator might
•compromise communication with the investigator
•14). Participation of patients in another clinical trial during the last 30 days
•15). Patients with known sensitivity (sensitivity) of perindopril or losartan
•or a chemically related components

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