Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors

Completed

• Conditions: Germ Cell Cancer

• Registration Number: NCT02303015
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The purpose of this study is to identify genetic variations in survivors of testicular cancer and connect these variations to differences in risks of late effects.

Detailed Description

Identification of late-effects through questionnaires and linkage to national registries. DNA samples will be gathered through buccal swabs or saliva kits and analysed with whole exome-sequencing.

Study Timeline

• Study Start: 2014-08
• Study First Submitted: 2014-11-25
• Study First Submitted QC: 2014-11-26
• Study First Posted: 2014-11-27
• Primary Completion: 2023-03
• Study Completion: 2023-06
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-19
• Last Update Posted: 2023-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 430

Inclusion Criteria

• Danish citizen
• Diagnosed with germ cell cancer from 1984 to 2007
• Treated initially at a Danish hospital
• Treated with standard treatment regimens.

Exclusion Criteria

• Treated initially at a foreign hospital

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal toxicity (Identify genetic variations predicting renal toxicity)	1 year	Identify genetic variations predicting renal toxicity.

Trial Locations

Locations (1)

Dept. of Oncology, Rigshospitalet; 🇩🇰 Copenhagen, Denmark