Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 2
- 主要终点
- Feasibility of the exergame development
研究概览
简要总结
The study will implement and test a unique Virtual Reality Cognitive Training (VRCT) combined with concurrent cycling on a recumbent stationary cycle, also known as exergame that seamlessly integrates specific cognitive tasks into a virtual environment and is synchronized with cycling to promote cognition.
详细描述
The proposed project will implement and test a unique Virtual Reality Cognitive Training (VRCT) combined with concurrent cycling on a recumbent stationary cycle, also known as exergame that seamlessly integrates specific cognitive tasks into a virtual environment and is synchronized with cycling to promote cognition. Cycling through an interesting virtual environment will motivate and engage the older adult to participate in the exercise, and VRCT could augment cycling's effects on cognition. The purpose of this project is to demonstrate the feasibility and efficacy of the exergame intervention on cognition through two phases. In Phase I, a prototype of the VRCT exergame will be developed, followed by a feasibility testing using a single-group mixed methods design. In Phase II a more fully-featured version of the VRCT exergame will be developed followed by a an RCT which will randomize subjects on a 2:1:1 allocation ratio to 3 parallel groups (exergame:cycling only:attention control). Mixed methods will be used to assess outcomes in both phases.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 99 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cognitive complaint (defined as answering yes to the question "Do you feel that your memory or thinking skills have gotten worse recently?)
- •Not engaging in aerobic exercise or cognitive training >2 days/week, 30 minutes a session in the past 3 months;
- •Age 65 years and older
排除标准
- •Resting heart rate > 100 or < 50 beats/min;
- •Dementia (self-report, diagnosis, or scoring <18 on the modified Telephone Interview for Cognitive Status;
- •Neurological or major psychiatric disorder since memory problem;
- •Significant diseases, symptoms, or other factors that make exercise unsafe
- •Current enrollment in another intervention study
结局指标
主要结局
Feasibility of the exergame development
时间窗: Baseline to 3 months
development of the exergame prototype by 3 months
次要结局
- Cycling adherence rate(3-6 months)
- Usability and satisfaction with the exergame(3-6 months)
- VCRT adherence rate(3-6 months)