Management of Non Obstructive Azoospermia in Men

Not Applicable

Completed

• Conditions: Male Infertility; Azoospermia, Nonobstructive

• Registration Number: NCT06983626
• Lead Sponsor: South Valley University

Brief Summary

this study predicts the factors of successful micro testicular sperm extraction in azoospermia patients in male infertility

Detailed Description

primary outcomes: these factors were the age, testicular size, hormonal, evidence of varicocles and the out come of Micro_TESE secondary outcomes: make good decision for Micro-TESE with low economic laboratory and radiology requirement As every failed microTESE-ICSI procedure exposes the couple to an emotional, financial burden and increase the incidence of complication such as bleeding, hematoma and testicular atrophy

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2024-04-01
• Status Verified: 2025-04
• Study Completion: 2025-04-01
• Study First Submitted: 2025-04-28
• Study First Submitted QC: 2025-05-14
• Last Update Submitted: 2025-05-14
• Study First Posted: 2025-05-21
• Last Update Posted: 2025-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 300

Inclusion Criteria

Non obstructive Azoospermia

Exclusion Criteria

• obstructive Azoospermia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Sperm Retrieval Success Rate and identification of Predictive Factors	1st 1 year	Determine which preoperative factors are significantly associated with successful sperm retrieval. These may include: Serum Follicle-Stimulating Hormone (FSH) Levels: Elevated FSH levels have been linked to reduced sperm retrieval success.; And patient Age and testicular size to reach the best one to predict the success rate

Secondary Outcome Measures

Name	Time	Method
Assess the success rates of ART procedures following sperm retrieval and complications	2 years	Assisted Reproductive Technology (ART) Outcomes; Fertilization Rates: The percentage of oocytes successfully fertilized.; Embryo Development: Quality and progression of embryos to the blastocyst stage.; Clinical Pregnancy Rates: Confirmed pregnancies via ultrasound.; Live Birth Rates: The ultimate success metric of ART procedures; Complication Rates; Monitor and document any complications arising from the sperm retrieval procedure, such as: Testicular Hematoma; Infection; Testicular Atrophy

Trial Locations

Locations (1)

Faculty of Medicine, South Valley University; 🇪🇬 Luxor, Qena, Egypt