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Clinical Trials/NCT01884142
NCT01884142
Completed
Not Applicable

Effects of Exercise Training on Mechanoreflex and Metaboreflex Control of Muscle Sympathetic Nerve Activity in Heart Failure Patients

University of Sao Paulo General Hospital1 site in 1 country34 target enrollmentMarch 2008
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ConditionsHeart Failure

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Heart Failure
Sponsor
University of Sao Paulo General Hospital
Enrollment
34
Locations
1
Primary Endpoint
Muscular Evaluation
Status
Completed
Last Updated
5 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.

Registry
clinicaltrials.gov
Start Date
March 2008
End Date
January 2014
Last Updated
5 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Lígia M. Antunes-Correa

PhD student

University of Sao Paulo General Hospital

Eligibility Criteria

Inclusion Criteria

  • •Patients with systolic heart failure;
  • •New York Heart Association (NYHA) class II-III;
  • •Left ventricular ejection fraction less than 40%;
  • •Peak Oxygen Consumption less than 20 ml/Kg/min;
  • •Stable Clinical Status.

Exclusion Criteria

  • •Chronic Obstructive Pulmonary Disease;
  • •Neuromuscular Diseases;
  • •Orthopedic Diseases;
  • •Neurologic Diseases;
  • •Neoplastic Diseases;
  • •Recent myocardial infarction or cardiac surgery (less than 6 months);
  • •Unstable angina pectoris;
  • •Atrial Fibrillation;
  • •Pacemakers users;
  • •Changing medication or hospital admission.

Outcomes

Primary Outcomes

Muscular Evaluation

Time Frame: 4 months

Muscular evaluation will be done by muscle gene expression

Autonomic Control

Time Frame: 4 months

Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest

Secondary Outcomes

  • Muscle Blood Flow(4 months)
  • Functional Capacity(4 months)
  • Blood Pressure(4 months)

Study Sites (1)

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