Effects of Exercise Training on Mechanoreflex and Metaboreflex Control in Heart Failure Patients
Not Applicable
Completed
- Conditions
- Heart Failure
- Interventions
- Other: Aerobic Exercise Training
- Registration Number
- NCT01884142
- Lead Sponsor
- University of Sao Paulo General Hospital
- Brief Summary
The investigators hypothesize that exercise training would improve the mechanoreflex and metaboreflex control in heart failure patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
- Patients with systolic heart failure;
- New York Heart Association (NYHA) class II-III;
- Left ventricular ejection fraction less than 40%;
- Peak Oxygen Consumption less than 20 ml/Kg/min;
- Stable Clinical Status.
Exclusion Criteria
- Chronic Obstructive Pulmonary Disease;
- Neuromuscular Diseases;
- Orthopedic Diseases;
- Neurologic Diseases;
- Neoplastic Diseases;
- Recent myocardial infarction or cardiac surgery (less than 6 months);
- Unstable angina pectoris;
- Atrial Fibrillation;
- Pacemakers users;
- Changing medication or hospital admission.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Heart Failure Exercise-trained Group Aerobic Exercise Training Aerobic Exercise Training
- Primary Outcome Measures
Name Time Method Muscular Evaluation 4 months Muscular evaluation will be done by muscle gene expression
Autonomic Control 4 months Mechanoreceptors were activated by passive exercise and metaboreceptors by post-exercise circulatory arrest
- Secondary Outcome Measures
Name Time Method Functional Capacity 4 months Functional Capacity will be determined by cardiopulmonary exercise testing
Muscle Blood Flow 4 months Forearm blood flow will be assessed by venous occlusion plethysmography
Blood Pressure 4 months Blood pressure will be monitored non-invasively
Trial Locations
- Locations (1)
Heart Institute (InCor), University of Sao Paulo Medical School
🇧🇷Sao Paulo, Brazil