Regulation of Apoptosis in Cultured Nasal Airway Epithelial Cells of Childre

• Conditions: programmed celdeath; 10038716

• Registration Number: NL-OMON31297
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

age 2-24 months
patient of: Emma Children's Hospital (outpatient clinic / ward)

Exclusion Criteria

History of pulmonary disorder
No permission of caretakers

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Evidence for apoptosis: caspase-3 activity, annexin-V binding and morphological<br /><br>studies.<br /><br>Apoptotic pathways: RNA of the Bcl-2 and IAP family of pro- and anti-apoptotic<br /><br>factors, RNA and protein analysis of Fas/FasL and caspase-8 and -9 activity. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>