Regulation of apoptosis in cultured airway epithelial cells of infants
- Conditions
- 10038716
- Registration Number
- NL-OMON29743
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Age: 2 - 24 months.
Endotracheally intubated for elective surgery for non-pulmonary disorders at the Academic Medical Center in Amsterdam.
Exclusion Criteria
Age under 2- or above 24 months.
History of pulmonary disorder.
No permission form parents or guardian.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Evidence for apoptosis: caspase-3 activity, annexin-V binding and morphological<br /><br>studies.<br /><br>Apoptotic pathways: RNA of the Bcl-2 and IAP family of pro- and anti-apoptotic<br /><br>factors, RNA and protein analysis of Fas/FasL and caspase-8 and -9 activity.</p><br>
- Secondary Outcome Measures
Name Time Method <p>none</p><br>