APOPTOSIS OF ALVEOLAR EPITHELIAL CELLS DURING MECHANICAL VENTILATION IN CHILDRE

• Conditions: programmed cell death in the lung; pulmonary epithelial cell apoptosis; 10038716

• Registration Number: NL-OMON30000
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

All children younger than 5 years of age who are admitted to the PICU for mechanical ventilation

Exclusion Criteria

- PaO2/FiO2 ratio <33.3 kPa (250 mm Hg)
- Platelets < 50*109/l, APTT or PTT > 1.5 normal value
- No permission form parents or care takers

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Soluble death receptor ligands sFasL (relatively to sFas) and TNF*/TRAIL (by<br /><br>ELISA)<br /><br><br /><br>Granzyme A and B, cleaved cytokeratin 18 (by M30 based ELISA)<br /><br><br /><br>Active Angiotensin Coverting Enzyme and Angiotensin II as a parameter of death<br /><br>receptor apoptosis<br /><br><br /><br>Total protein, IgM and Albumin, total cell and differential count.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>