Geriatric anti-donor T-cell activity and development of alloreactive long-term hypo-responsive T cell function (GANDALF); Post-transplant development of anti-donor-specific hypo-responsiveness; Lessons to be learned from older kidney transplant recipients

Recruiting

• Conditions: orgaantransplantatie; anti-donor immunity; post-transplant anti-donor reactivity

• Registration Number: NL-OMON48839
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 540

Inclusion Criteria

-18 years or older; i.e. between 18-45 years and >54 years
-kidney transplant recipient who is supervised at the Erasmus University
Medical Center in Rotterdam
-recipient of a living or post mortal donor kidney
-stable graft function (defined as absence of recurrence disease and chronic
rejection) 3-5
or 5-10, 10-15, 15-20 and >20 years after transplantation (cross-sectional
sub-study)

Exclusion Criteria

age<18 years and 46-54 years

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter comprises of a detailed characterization of<br /><br>anti-donor reactivity at different time-points following kidney transplantation<br /><br>to identify the mechanism(s) of DSH.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>