The effect of curcumin piperine supplementation on inflammation, length of stay, and 28-day mortality in patients with sepsis admitted to the intensive care unit (ICU): a double-blind randomized controlled clinical trial

Esfahan University of Medical Sciences0 个研究点目标入组 50 人开始时间: 待定最近更新: 2022年5月2日

试验速览

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•Age 20-60 years
•Gastrointestinal tract with normal function and intestinal nutrition criteria
•Diagnosis of sepsis is based on blood culture and the approval of an ICU, anesthesiologist and infectious disease specialist

•Impossibility of intestinal feeding in the first 48 hours of admission
•Any history of underlying heart disease
•Patients who are hospitalized in the intensive care unit for less than 48 hours
•Patients who are expected to die within 12 hours of admission to the intensive care unit.
•Patients who do not have an indication for intestinal nutrition on the first day and are confirmed and predicted based on the diagnosis of the intensive care unit that they will not be able to receive intestinal nutrition in the future. (Nausea, persistent vomiting, ileus, intestinal obstruction, uncontrolled diarrhea (> 500 ml per day), high-output fistula (> 500 ml per day), intestinal inaccessibility, incomplete resuscitation and hemodynamic
•Patients with BMI <18.5 kg / m2 admitted to the intensive care unit.
•Patients who receive nutritional support through complete intravenous feeding
•Patients with a history of underlying disease such as diabetes, congenital and immune disorders, renal and hepatic insufficiency, and pancreatitis.
•Taking anticoagulants such as heparin, warfarin, aspirin, etc.
•Pregnancy and lactation
•Severe septic shock or sepsis
•Dissatisfaction of the patient or her legal guardian

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