Effect of prolonged prone positioning on intubation rate and mortality in noninvasively ventilated patients with SARS-CoV-2 pneumonia and moderate-to-severe hypoxemic respiratory failure: a controlled trial

Ospedale Humanitas Gradenigo0 个研究点目标入组 138 人开始时间: 2021年6月2日最近更新: 2024年7月29日

适应症

试验速览

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35488356/ (added 03/05/2022) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37232709/ (added 30/05/2023) 2023 Results article in https://doi.org/10.1007/s13167-023-00325-5 (added 19/07/2024)

•1. Presence of acute (i.e. symptom onset <14 days of hospital access) hypoxemic respiratory failure
•2. Confirmed severe SARS-CoV-2 pneumonia based on the Center for Disease Control guidelines: SARS-CoV-2 infection confirmed by PCR AND bilateral opacities on chest X-ray or CT scan not fully explained by effusions, lobar or lung collapse, or nodules, with sO2<90% in room air on pulse oxymetry
•4. Cardiac failure not the primary cause of acute respiratory failure
•5. Moderate to severe hypoxemia, defined by a PaO2/FiO2 ratio <200 mm Hg while receiving oxygen therapy through either a Venturi mask with FiO2 50% or a non-rebreather reservoir bag-mask, with FiO2 estimated as 0.21+ oxygen flow rate in L/min×3

•1. Age less than 18 years-old
•2. Pregnancy
•3. Immediate need of invasive mechanical ventilation (altered mental status, fatigue, hemodynamic instability).
•4. Contraindications for prone positioning therapy (recent abdominal or thoracic surgery or wound; facial, pelvic, or spine fracture)
•5. Vomiting or bowel obstruction
•6. Palliative care
•7. Multiorgan failure
•8. Pneumothorax
•9. Inability of the patient to provide informed consent
•10. Uncooperativeness or refusal to lie on abdomen for at least 8 hours

发起方

Ospedale Humanitas Gradenigo