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Clinical Trials/NL-OMON41412
NL-OMON41412
Completed
Not Applicable

Mechanisms underlying the development of autism: a multi-site prospective study in very young high-risk siblings and controls - Development of autism

niversitair Medisch Centrum Sint Radboud0 sites105 target enrollmentTBD
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ConditionsAutism Spectrum Disorderautism10012562

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Autism Spectrum Disorder
Sponsor
niversitair Medisch Centrum Sint Radboud
Enrollment
105
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational non invasive

Investigators

Sponsor
niversitair Medisch Centrum Sint Radboud

Eligibility Criteria

Inclusion Criteria

  • •High\-risk siblings:
  • •\- Age between 4 months and 6 months OR younger than 11 months
  • •\- Older full sibling with ASD (clinical diagnosis autism, PDD\-NOS or Asperger syndrome)
  • •\- At least one parent speaks Dutch to child at home (does not need to be parent\*s native language);Controls:
  • •\- Age between 4 months and 6 months OR younger than 11 months
  • •\- Older full sibling with typical development (by parent report)
  • •\- At least one parent speaks Dutch to child at home (does not need to be parent\*s native language)

Exclusion Criteria

  • •High\-risk siblings:
  • •\- Diagnosis of epilepsy or history of fits/convulsions
  • •\- Presence of genetic syndrome (in proband or infant) clearly related to ASD (e.g. Tuberous Sclerosis, Fragile\-X)
  • •\- Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health professional)
  • •\- Infant was premature (pre 36 weeks)
  • •\- Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant\*s care.
  • •\- Presence of known significant developmental or medical condition in infant likely to affect brain development or infant\*s ability to participate in the study (e.g. Cerebral Palsy, Down\*s syndrome, cystic fibrosis, foetal alcohol syndrome);Low\-risk:
  • •\- Diagnosis of epilepsy or history of fits/convulsions
  • •\- Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health professional)
  • •\- Infant was premature (pre 36 weeks)

Outcomes

Primary Outcomes

Not specified

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