NL-OMON41412已完成不适用
Mechanisms underlying the development of autism: a multi-site prospective study in very young high-risk siblings and controls - Development of autism
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 105 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 2 至 11（—）
入选标准
- •High-risk siblings:
- •- Age between 4 months and 6 months OR younger than 11 months
- •- Older full sibling with ASD (clinical diagnosis autism, PDD-NOS or Asperger syndrome)
- •- At least one parent speaks Dutch to child at home (does not need to be parent*s native language);Controls:
- •- Age between 4 months and 6 months OR younger than 11 months
- •- Older full sibling with typical development (by parent report)
- •- At least one parent speaks Dutch to child at home (does not need to be parent*s native language)
排除标准
- •High-risk siblings:
- •- Diagnosis of epilepsy or history of fits/convulsions
- •- Presence of genetic syndrome (in proband or infant) clearly related to ASD (e.g. Tuberous Sclerosis, Fragile-X)
- •- Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health professional)
- •- Infant was premature (pre 36 weeks)
- •- Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant*s care.
- •- Presence of known significant developmental or medical condition in infant likely to affect brain development or infant*s ability to participate in the study (e.g. Cerebral Palsy, Down*s syndrome, cystic fibrosis, foetal alcohol syndrome);Low-risk:
- •- Diagnosis of epilepsy or history of fits/convulsions
- •- Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health professional)
- •- Infant was premature (pre 36 weeks)
- •- Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant*s care.
- •- Presence of known significant developmental or medical condition in infant likely to affect brain development or infant*s ability to participate in the study (e.g. Cerebral Palsy, Down*s syndrome, cystic fibrosis)
- •- Interested in study because parents are concerned that their infant is developing ASD, despite negative family loadings
- •- Presence of ASD in 1st degree relatives
研究者
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