Autism: from phenotype to genotype and back
Withdrawn
- Conditions
- Autism spectrum disordersPervasive developmental disorders10012562
- Registration Number
- NL-OMON41644
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 4500
Inclusion Criteria
The diagnosis of ASD in the proband, according to the DSM-IV (APA 1994) or DSM-5criteria, established by an expert clinician.
Proband age between 5 and 25 years.
Availability of at least 1 biological parent
Exclusion Criteria
Proband younger than 5 or older than 25 years of age.
Family members of the proband: no age exclusion criteria.
Epilepsy and/or mental retardation are not criteria for exclusion
Known genetic disorders at entry (e.g. fragile X) are not a reason for exclusion, however such conditions will be noted in the participant*s research file.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>(1) Non-synonymous single nucleotide changes in DNA coding sequence<br /><br>(2) Copy number variants</p><br>
- Secondary Outcome Measures
Name Time Method <p>(1) Nature and severity of autistic symptoms<br /><br>(2) Nature and severity of co-morbid psychiatric symptoms<br /><br>Potential confounding factors including age, gender, years and level of<br /><br>education, years and level of parental education, medication use.</p><br>