ocal gentamicin in Redon treated post-sternotomy mediastinitis

Phase 4

Completed

• Conditions: Post-sternotomy mediastintis; surgical site infection after cardiac surgery; 10004018; 10069888; 10007593

• Registration Number: NL-OMON41174
• Lead Sponsor: Sint Antonius Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Age above 18 years
- Underwent a cardiothoracic procedure through median sternotomy
- Clinical signs of PSM as described by the Centres for Disease Control and Prevention (CDC)

Exclusion Criteria

- Patients with severe renal failure (serum creatinine above 150 µmol/L)
- Patients with neuromuscular diseases
- Patients who are allergic for aminoglycosides
- Patients with systemic lupus erythematosus, scleroderma or chronic polyarthritis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Hospital stay</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In-hospital mortality<br /><br>Duration of wound sterilization<br /><br>Duration of antibiotic treatment<br /><br>Duration of drainage<br /><br>CRP decline<br /><br>Leukocyte decline</p><br>