Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease

Completed

• Conditions: Hairy Cell Leukemia; Splenic Marginal Zone Lymphoma

• Registration Number: NCT01720758
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. The finding of this specific mutation will help to verify or exclude the diagnosis of Hairy Cell Leukemia and determine whether patients are in remission.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-10-31
• Study Start: 2012-11
• Study First Submitted QC: 2012-11-01
• Study First Posted: 2012-11-02
• Primary Completion: 2013-03
• Study Completion: 2013-04
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-10
• Last Update Posted: 2017-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients over the age of 18 years -

Exclusion Criteria

Patients less than 18 years in age or mentally defectives.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
detection of the B-RAF V600E mutation	2 weeks