Assessment of Serum Levels of Adenosine Deaminase and Immunoglobulin E in Patients With Chronic Spontaneous Urticaria

Not yet recruiting

• Conditions: Chronic Spontaneous Urticaria
• Interventions: Diagnostic Test: Adenosine deaminase serum level; Diagnostic Test: IgE antibodies serum level

• Registration Number: NCT05992987
• Lead Sponsor: Sohag University

Brief Summary

adenosine deaminase activity (ADA) has been reported to be elevated in various diseases such as psoriasis, acne and juvenile idiopathic arthritis. There is no previous studies that assessed ADA in chronic spontaneous urticaria (CSU) .

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-08-07
• Study First Submitted QC: 2023-08-07
• Last Update Submitted: 2023-08-07
• Study Start: 2023-08-15
• Study First Posted: 2023-08-15
• Last Update Posted: 2023-08-15
• Primary Completion: 2023-12-31
• Study Completion: 2024-03-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• adult patients complaining of CSU and a group of age and sex-matched healthy controls (blood donors).

Exclusion Criteria

• Pregnancy and lactation.
• Patients with systemic diseases, especially those with autoimmune diseases and infections.
• Patients with skin diseases.
• Patients on medications such as antibiotics, nonsteroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors, anticonvulsants, penicillin, and combined oral contraceptives.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control group	Adenosine deaminase serum level	A group of age and sex-matched healthy controls (blood donors).
Control group	IgE antibodies serum level	A group of age and sex-matched healthy controls (blood donors).
CSU group	Adenosine deaminase serum level	Adult patients complaining of chronic spontaneous urticaria (CSU)
CSU group	IgE antibodies serum level	Adult patients complaining of chronic spontaneous urticaria (CSU)

Primary Outcome Measures

Name	Time	Method
Serum level of IgE	3 months	Difference in serum level of IgE between CSU group and control group
Serum level of adenosine deaminase	3 months	Difference in serum level of adenosine deaminase between CSU group and control group