Mitochondrial function and markers of oxidative stress in patients with organ failure
Not Applicable
Recruiting
- Conditions
- Organ failure in septic shockOrgan failure in shock without sepsisInflammatory and Immune System - Other inflammatory or immune system disordersCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12612000047897
- Lead Sponsor
- Auckland City Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
For patients: Over 15 with either septic shock or shock from any other cause. All patients must have organ failure of one or more organ systems.
For heathy volunteers: Over 15 without any known medical conditions and not on any medications. Age and gender matched to patients. Eligible healthy volunteers will be deemed healthy with a help of a questionnaire detailing their medical history.
Exclusion Criteria
Exclusion criteria for patients: Known mitochondrial diseases, hematological malignancies are the exclusion criteria for participating patients.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mitochondrial respiratory function by using the technique of high resolution respirometry using machines called oxygraphs[For patients with septic shock/shock without sepsis: Daily for the first 7 days, once in 3rd week, once at 6 months<br>For healthy volunteers: Peripheral blood taken twice within 1 month from the first blood take]
- Secondary Outcome Measures
Name Time Method Mitochondrial reactive oxygen species production by measuring superoxide production using flow cytometry equipment.[For patients with septic shock/shock without sepsis: Daily for the first 7 days, once in 3rd week, once at 6 months<br>For healthy volunteers: Peripheral blood taken twice within 1 month from the first blood take];Fatigue questionnaire score[For patients only: at 6 months]