CLINICAL AND RADIOGRAPHIC ASSESSMENT OF BONE REGENERATION USING ALENDRONATE SODIUM GEL IN CHRONIC PERIODONTITIS (an inflammatory condition affecting the tissues that surround and support the teeth).

Not Applicable

Completed

• Registration Number: CTRI/2013/01/003286
• Lead Sponsor: PRINCIPAL INVESTIGATOR

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

a)Patient of either sex within the age group of 35-50 years.

b)Systemically healthy patients.

c)Clinical diagnosis of moderate generalized chronic periodontitis.

d)Patients with probing depth >=5 mm or clinical attachment loss > 4 to 6 mm bilaterally as evidenced by clinical examination.

e)Patients with vertical bone loss > 5mm as evidenced on IOPA radiograph.

f)Patients with acceptable oral hygiene following Phase-I therapy.

Exclusion Criteria

a)Patients with presence of systemic conditions or disease affecting bone density e.g. Osteoporosis, Pagetâ??s disease.

b)Patients with known or suspected allergy to Alendronate/ bisphosphonates group.

c)Patients with Aggressive Periodontitis.

d)Patients with horizontal bone loss.

e)Patients without any contradictions for periodontal surgery.

f)Patients with a history of drug intake that can affect bone metabolism in the past 6 months. E.g. NSAIDs.

g)Patients who are current smokers, or ex smokers for less than five years.

h)Pregnant or lactating females.

i)Patients who are alcoholics.

j)Immunocompromised patients.

k)Patients using tobacco in any form.

l)Patients with gross oral pathology, tumors which can alter the course of periodontal

disease.

m)Patients who have taken medications affecting periodontal status or has received periodontal therapy in the preceding six months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
â?¢To assess the bone regeneration in osseous defects clinically <br/ ><br> <br/ ><br>â?¢To assess the bone regeneration in osseous defects radiographicallyTimepoint: Recall Appointments at 1 month, 3 month, 6 month & 9 month post surgery intervals for post operative review and clinical and radiological assessment.

Secondary Outcome Measures

Name	Time	Method
Baseline clinical parameters like Bleeding on Probing, Gingival Index, Periodontal Probing Depth and Clinical Attachment Level of all the patients will be measured followed by radiographic assessment by intra-oral radiograph.Timepoint: Recall Appointments at 1 month, 3 month, 6 month & 9 month post surgery intervals for post operative review and clinical and radiological assessment.