NCT00926055撤回不适用
Effects on Atherosclerosis Regression of Ezetimibe Monotherapy or Ezetimibe Plus Simvastatin Combination Therapy: Evaluation by Fluorodeoxyglucose Positron Emission Tomography
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- The difference of FDG uptake quantified by measuring the standardized uptake value (SUV) corrected for body weight according to the treatment groups
研究概览
简要总结
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques. Therefore, in this study the investigators intend to compare the effect of ezetimibe monotherapy or ezetimibe plus statin combination therapy on the atherosclerosis regression using FDG-PET.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •hsCRP > 2 mg/L and LDL cholesterol > 130 mm/dL
排除标准
- •history of cardiovascular disease
- •uncontrolled hypertension
- •active infection
- •previous anti-hyperlipidemic agents within 6 months
- •previous steroid or anti-inflammatory agents within 6 months
- •liver disease
- •renal disease
研究组 & 干预措施
Ezetimibe
Active Comparator
干预措施: Ezetrol (Ezetimibe) (Drug)
Ezetimibe/Simvastatin
Experimental
干预措施: Vytorin (Ezetimibe + Simvastatin) (Drug)
结局指标
主要结局
The difference of FDG uptake quantified by measuring the standardized uptake value (SUV) corrected for body weight according to the treatment groups
时间窗: 3 months later
次要结局
未报告次要终点
研究者
研究点 (1)
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