on-invasive biomarkers of UV-radiatio
Completed
- Conditions
- skin cancer10014982
- Registration Number
- NL-OMON47995
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
* Male individuals between 18 and 65 years.
* Fitzpatrick skin types II or III.
* Individuals free of any dermatological or systemic disorder which would interfere with the results, at the discretion of the investigator.
* Individuals who have read, understood and signed an informed consent document relat-ing to the specific study to which they are subscribing.
* Individuals with no known abnormal response to sunlight (e.g. polymorphic eruption).
Exclusion Criteria
* Individuals taking medication which in the opinion of the investigator would mask or in-terfere with the results.
* Individuals with chronic skin allergies.
* Individuals with abnormal reaction to the sun.
* Subjects who used sun beds in the previous 30 days.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The levels of urocanic acid isomers, MMP, cytokines and DNA-photoproducts<br /><br>measured in the stratum corneum and/or urine at different time points during a<br /><br>3-weeks study</p><br>
- Secondary Outcome Measures
Name Time Method <p>The levels of urocanic acid isomers, MMP, cytokines and DNA-photoproducts at<br /><br>different stratum corneum depths (i.e. 1st to 12th collected tape from the same<br /><br>skin site)</p><br>