Biomarkers of ultraviolet radiation exposure

Not Applicable

Completed

• Conditions: Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology; Skin and Connective Tissue Diseases; Dermatology

• Registration Number: ISRCTN97738113
• Lead Sponsor: niversity of Manchester (UK)

Brief Summary

2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29730334 results (added 22/01/2019)

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07-19
• Study Completion: 2014-05-31
• Last Update Posted: 7 November 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

1. Healthy, ambulant human volunteers
2. Aged 18-45 years
3. Sun reactive skin types I-VI
4. Non smokers
5. Body mass index (BMI) of less than 30

Exclusion Criteria

1. History of skin cancer or photosensitivity disorder
2. Taking photoactive medication
3. Sunbathing or sunbed use in the past 3 months
4. Taking dietary supplements containing vitamin D or antioxidants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
rinary DNA damage; Timepoint(s): Up to 14 days post exposure

Secondary Outcome Measures

Name	Time	Method
<br> 1. Time of maximal DNA damage product concentration in urine following acute UVR exposure<br> 2. Minimum dose of UVR required to produce detectable levels of DNA damage in urine<br> 3. Level of DNA damage in skin biopsy sections following acute UVR<br> 4. Concentration of serum 25(OH)D following acute UVR exposure<br>