Conservative versus liberal fluid therapy in patients with liver disease admitted to the intensive care unit.

Phase 3

• Conditions: cirrhosis; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12615000377538
• Lead Sponsor: Professor Rinaldo Bellomo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1.Adults (>18 years) admitted to ICU with decompensated cirrhosis
2.Hypotension (Mean Arterial Pressure (MAP) <65mmHg)
3.Clinical need for of a Central Venous Catheter (CVC) and arterial line (capable of cardiac output measurement (e.g. PiCCO or FloTrac)

Exclusion Criteria

*Fulminant Hepatic Failure
*Oliguria requiring frusemide administration via a continuous infusion prior to or immediately on admission to ICU
*Renal failure requiring renal replacement therapy prior to or immediately on admission to ICU
*Diagnosis of Acute Respiratory Distress Syndrome (ARDS)
New, bilateral pulmonary infiltrates evident on chest X-Ray
Absence of clinical evidence for, or measured findings of left atrial hypertension
PaO2:FiO2 ratio of <200
*Severe pre-existing cardiopulmonary disease, e.g.;
NYHA class III or IV heart failure
Pulmonary hypertension
*Admission to ICU for severe bleeding (e.g. oesophageal varices complicated by haemorrhage)
*Requirement for total parenteral nutrition (TPN)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in serum creatinine as documented in clinical record<br>[4 days after study enrolment];Change NephroCheck test score as documented in clinical record<br>[4 days after enrollment];Fluid balance/weight as documented in clinical record<br>[4 days post enrolment]