The effect of Esmolol before cardioplegia and as a combination in cardioplegia on biochemical markers of myocardial injury in patients undergoing coronary artery bypass graft surgery

Phase 3

Conditions: coronary Artery disease.
Atherosclerotic heart disease of native coronary artery
I25.1

Registration Number: IRCT20180428039456N1

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 280

Inclusion Criteria

Only coronary bypass grafting surgery candidates due to coronary artery disease and atherosclerosis
Left ventricular Ejection fraction between 45-60%
Left ventricle end diastole Diameter (LVEDD) less than 60 mm
Age above 18 years old
Not having diabetes mellitus type 2 or consuming any oral hypoglycemic agents
Not having severe systemic diseases (including any pulmonary, hepatic, renal, and musculoskeletal diseases or immune system illnesses)
Not participating in any other studies
Not having any confirmed arrhythmia or consuming any anti-arrhythmic agents (except beta-blockers)

Exclusion Criteria

Not willing to participate in the study
No need for emergency operation
No history of inappropriate reaction to Esmolol
Not received Esmolol over the past 30 days

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Average of cardiac biomarkers Troponin I, CK-MB and LDH. Timepoint: Measurement of biochemical markers of myocardial injury before and 4, 12, 24 and 48 hours after surgery. Method of measurement: Patient blood samples and laboratory measurements.

Secondary Outcome Measures

Name	Time	Method
Frequency of ventricular fibrillation during the heart re-beat. Timepoint: After unclamping the aorta. Method of measurement: Electrocardiogram.;Hours of ICU stay. Timepoint: After the surgery. Method of measurement: hours documented in the charts.;Duration of patient admission after surgery in hospital. Timepoint: Number of hospital admission days in the post-operative. Method of measurement: Follow patient.;Need for inotropic drugs. Timepoint: Check the number of inotropes used. Method of measurement: Follow patient.